I am using nap on the django side (json/mapping) http://django-nap.readthedocs.io/en/latest/index.html and axios https://github.com/mzabriskie/axios on the vuejs side (http) There are many other options and configurations. I settled on a modular architecture because I like to worry about one thing at a time :) You can also look at vue-resource (and others) and DRF https://www.django-rest-framework.org/ I am still learning vue as I go along but it is so well designed its a pleasure to learn as well