I want to point out that it works perfectly fine making a JavaScript web app in just vanilla JavaScript using NodeJS as server and the browser as client. You do not need any frameworks!!
You just end up inventing your own framework this way. You'll come across problems, come up with some solution you think is clever, come up with conventions to follow etc. Surprise! You've just manually rediscovered all the problems frameworks were created to solved and reinvented the wheel.
I'll use vanilla JavaScript or jQuery if the UI required is really basic but anything beyond that, you're going to save time using a well thought out framework rather than thinking you're smarter than whole communities who have spent years working on these solutions. Coders don't invent frameworks for the sake of it, they exist for a reason.
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You just end up inventing your own framework this way. You'll come across problems, come up with some solution you think is clever, come up with conventions to follow etc. Surprise! You've just manually rediscovered all the problems frameworks were created to solved and reinvented the wheel.
I'll use vanilla JavaScript or jQuery if the UI required is really basic but anything beyond that, you're going to save time using a well thought out framework rather than thinking you're smarter than whole communities who have spent years working on these solutions. Coders don't invent frameworks for the sake of it, they exist for a reason.