I'm using Ubuntu but this should still apply to OS X. SimCity 4 works nearly perfectly (both software & hardware rendering) under Wine. There used to be a problem with the installer but based on test results on the Wine AppDB that works now too. Also you can set a custom resolution using "-CustomResolution:enabled" and using eg. "-r1440x900x32" which helps make the game more playable on widescreen monitors. I used to run SimCity under VirtualBox but with larger populations it's much faster under wine.
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I'm using Ubuntu but this should still apply to OS X. SimCity 4 works nearly perfectly (both software & hardware rendering) under Wine. There used to be a problem with the installer but based on test results on the Wine AppDB that works now too. Also you can set a custom resolution using "-CustomResolution:enabled" and using eg. "-r1440x900x32" which helps make the game more playable on widescreen monitors. I used to run SimCity under VirtualBox but with larger populations it's much faster under wine.