I'm not saying to avoid it because of regulatory burden, but because of unknown regulatory burdens.

You can plan for known regulatory burdens. For instance, in the automotive industry, just add millions of dollars worth of safety testing to your R&D budget. If the business plan still works, run with it, and calculate odds. In the defense industry, make sure you hire lots of lobbyists.

It's the unknown unknowns, not the known unknowns that will kill you.