I've done exactly this in my MBP and been very pleased. 80GB X25-M as the primary drive, and a larger disk as the secondary drive.
As an aside -- for whatever reason, I couldn't get my optical drive to work in the enclosure provided with the Optibay. I didn't investigate too much, since it just doesn't matter to me.
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You can get two hard drives on a MBP if you're willing to sacrifice your dvd drive:
http://www.mcetech.com/optibay/
I've done exactly this in my MBP and been very pleased. 80GB X25-M as the primary drive, and a larger disk as the secondary drive.
As an aside -- for whatever reason, I couldn't get my optical drive to work in the enclosure provided with the Optibay. I didn't investigate too much, since it just doesn't matter to me.